Let’s get positive: How foreign language teaching enjoyment can create a positive feedback loop

How to create a positive workplace.

2. What can you do to start sharing your “no complaining” ideas with the whole team? Write your ideas here. _____________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ 3. Use this exercise for yourself, and then with y...

Positive Feedback in a Brainstem Tactile Sensorimotor Loop

The trigeminal loop in the brainstem comprises the innermost level of sensorimotor feedback in the rat vibrissa system. Anatomy suggests that this loop relays tactile information from the vibrissae to the motoneurons that control vibrissa movement. We demonstrate, using in vitro and in vivo recordings, that the trigeminal loop consists of excitatory pathways from vibrissa sensory inputs to vibr...

Amplification of dopaminergic signaling by a positive feedback loop.

Dopamine and cAMP-regulated phosphoprotein of M(r) 32,000 (DARPP-32) plays an obligatory role in most of the actions of dopamine. In resting neostriatal slices, cyclin-dependent kinase 5 (Cdk5) phosphorylates DARPP-32 at Thr-75, thereby reducing the efficacy of dopaminergic signaling. We report here that dopamine, in slices, and acute cocaine, in whole animals, decreases the state of phosphoryl...

A Positive Feedback Loop of IL-21 Signaling

Fibrotic extracellular matrix activates a profibrotic positive feedback loop.

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF are not well defined. Here, we examined how the interplay between the ECM and fibroblasts affects ...